Down-regulation of colon mucin production induced by Eimeria pragensis infection in mice
Our findings suggested that <i>E. pragensis</i> infection induces a mucosal barrier dysfunction in the early phase of the infection, which possibly causes the tissue invasion of bacteria in the large intestine. Th1-type inflammatory response, thus induced, reduces goblet cell numbers and mucin production. This model provides valuable insight into the mechanisms of mucosal barrier disruption during protozoan infection.
Authors
- Mio Tanaka (ORCID: https://orcid.org/0000-0002-0755-8483)
- Akemi Yoshida
- Ryusei Tanaka (ORCID: https://orcid.org/0009-0000-0334-2936)
- Ayako Yoshida (ORCID: https://orcid.org/0000-0002-3668-9001)
- Eiji Nagayasu
- Haruhiko Maruyama (ORCID: https://orcid.org/0000-0001-6121-1387)
- Yulia Dwi Setia (ORCID: https://orcid.org/0000-0002-6972-0570)
- Parnian AHMADI
Institutions
- University of Miyazaki (JP)
- University of Brawijaya (ID)
- Virginia Commonwealth University (US)
Publication Details
- Journal
- Frontiers in Parasitology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fpara.2025.1621486
- Primary Topic
- Coccidia and coccidiosis research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Core Research for Evolutional Science and Technology