The microbial metabolite butyrate enhances the effector and memory functions of murine CD8+ T cells and improves anti-tumor activity
Our findings show that butyrate promotes the effector activity of CD8+ T cells in culture, which can persist <i>in vivo</i> while also stimulating memory phenotypes. Consequently, butyrate treatment may have strong application in T cell-based immunotherapies to improve protective cell functions and patient outcomes.
Authors
- Douglas Gaskarth
- Shunwu Fan (ORCID: https://orcid.org/0000-0003-1560-9065)
- Roslyn A. Kemp (ORCID: https://orcid.org/0000-0001-9092-1150)
- Andrew J. Highton (ORCID: https://orcid.org/0000-0003-3967-016X)
Institutions
- University of Otago (NZ)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fmed.2025.1577906
- Citations
- 7
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- University of Otago
- Cancer Society of New Zealand
- Maurice Wilkins Centre for Molecular Biodiscovery