Shared genetic loci connect cardiovascular disease with blood pressure and lipid traits in East Asian populations
Our findings provide comprehensive insight into the shared genetic determinants of cardiovascular and metabolic diseases in East Asian populations. The identification of pleiotropic and ancestry-specific loci, along with tissue-specific regulatory patterns, underscores the need for integrative multi-trait and population-informed approaches in cardiovascular genetics and risk prediction.
Authors
- Chumeng Zhang (ORCID: https://orcid.org/0000-0003-3391-9390)
- Xiao Chang (ORCID: https://orcid.org/0000-0002-0230-0416)
- Peng Zhong (ORCID: https://orcid.org/0000-0002-3199-2319)
- Qian Wu (ORCID: https://orcid.org/0000-0002-2936-2131)
Institutions
- Yuhuangding Hospital (CN)
- Jining First People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Frontiers in Genetics
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fgene.2025.1635378
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00