Multi-omics analysis identified macrophages as key contributors to sex-related differences in ulcerative colitis
RPS4Y1 exhibits sex-specific expression in UC and plays a key role in immunomodulation. Mitochondrial energy metabolism contributes to sex-based macrophage differences, highlighting the importance of considering sex-specific mechanisms in UC diagnosis and individualized treatment.
Authors
- Jiahao Yang (ORCID: https://orcid.org/0000-0001-5878-4563)
- Chenyun Miao (ORCID: https://orcid.org/0000-0001-7727-2870)
- Xiaobing Dou
- Xin Yin (ORCID: https://orcid.org/0000-0002-6200-2111)
- Yanyan Li (ORCID: https://orcid.org/0000-0002-2939-9065)
- Yang Liu (ORCID: https://orcid.org/0000-0002-5717-471X)
- Ying Lin (ORCID: https://orcid.org/0009-0005-2579-8930)
- Xiaojie Fang (ORCID: https://orcid.org/0000-0002-1511-1841)
Institutions
- Zhejiang Chinese Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fimmu.2025.1569271
- Citations
- 5
- Primary Topic
- Inflammatory Bowel Disease
- Type
- article
- Field-Weighted Citation Impact
- 9.09