Intravenous Diazepam Infusion in Tetanus: An Experience in Balancing a Unique Clinical Challenge

REPORTsensory stimuli, and eventually led to generalized body aches, spasms, opisthotonos, and difficulty in movement.The patient had not received a tetanus toxoid in the last 5 years and denied any relevant medical history.After two brief hospitalizations, he was referred to Indira Gandhi Institute of Medical Sciences (IGIMS) due to worsening symptoms.In the ICU, wound care was provided, along with tetanus immunoglobulin, tetanus toxoid, sedation, spasm management, and airway protection with intubation followed by tracheostomy.Due to unresponsive spasm control with midazolam, diazepam infusion was started for reducing spasm frequency.Complications, including autonomic dysfunction, rhabdomyolysis, recurrent hypoglycemia, and metabolic acidosis, were managed appropriately.Blood pressure

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Publication Details

Journal
Indian Journal of Critical Care Case Report
Published
2025-06-20
DOI
https://doi.org/10.5005/jp-journals-11006-0172
Primary Topic
Diphtheria, Corynebacterium, and Tetanus
Type
article
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article

Intravenous Diazepam Infusion in Tetanus: An Experience in Balancing a Unique Clinical Challenge

Ritu Singh, Sanjeev Kumar, Abhay Kumar, Ravi Prakash Yadav et al.
Indian Journal of Critical Care Case Report
Diphtheria, Corynebacterium, and Tetanus
article

Intravenous Diazepam Infusion in Tetanus: An Experience in Balancing a Unique Clinical Challenge

Ritu Singh, Sanjeev Kumar, Abhay Kumar, Ravi Prakash Yadav, Lokesh Kadam
article en

Abstract

REPORTsensory stimuli, and eventually led to generalized body aches, spasms, opisthotonos, and difficulty in movement.The patient had not received a tetanus toxoid in the last 5 years and denied any relevant medical history.After two brief hospitalizations, he was referred to Indira Gandhi Institute of Medical Sciences (IGIMS) due to worsening symptoms.In the ICU, wound care was provided, along with tetanus immunoglobulin, tetanus toxoid, sedation, spasm management, and airway protection with intubation followed by tracheostomy.Due to unresponsive spasm control with midazolam, diazepam infusion was started for reducing spasm frequency.Complications, including autonomic dysfunction, rhabdomyolysis, recurrent hypoglycemia, and metabolic acidosis, were managed appropriately.Blood pressure

Indian Journal of Critical Care Case ReportVol. 4(4)
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Diphtheria, Corynebacterium, and Tetanus
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Intravenous Diazepam Infusion in Tetanus: An Experience in Balancing a Unique Clinical Challenge — Ritu Singh, Sanjeev Kumar, et al. · Indian Journal of Critical Care Case Report (2025) | TGRS Research Map | TGRS