Nucleus-targeted protein delivery <i>via</i> lysine dendron conjugation
This study introduces lysine dendron (LD)-mediated protein conjugation for nucleus-targeted delivery. Using click chemistry, multivalent LD-protein architectures enhance cellular uptake and nuclear accumulation without extensive surface engineering. LD-modified RNase A shows superior nuclear delivery and antitumor efficacy <i>in vitro</i>/<i>in vivo</i>. This bioreversible strategy overcomes traditional limitations, offering a versatile platform for next-generation protein therapeutics.
Authors
- Jiumeng Zhang (ORCID: https://orcid.org/0000-0001-8775-6510)
- Xuli Feng (ORCID: https://orcid.org/0000-0003-0476-9346)
- Xiang Ling
- Dongmei Qi
- Zuowen Zhang (ORCID: https://orcid.org/0000-0001-7597-7674)
- Huijuan Yang (ORCID: https://orcid.org/0000-0003-4569-6454)
- Lan Yang (ORCID: https://orcid.org/0000-0002-6933-7790)
Institutions
- Chongqing University (CN)
- Jiangjin Central Hospital (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02971f
- Primary Topic
- RNA Interference and Gene Delivery
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chongqing University
- Natural Science Foundation of Chongqing
- Fundamental Research Funds for the Central Universities