Correlation Study of Interleukin-6 in Patients with Anemia of Inflammation and Chronic Periodontitis

目的：探究白介素-6及牙周指标在炎症性贫血(anemia of inflammation, AI)与慢性牙周炎(chronic periodontitis, CP)患者中的相关性。方法：收集2023年11月~2024年1月期间就诊于安徽医科大学附属巢湖医院患者(主要为血液内科、口腔科、体检中心)共计142人。AI患者根据慢性牙周炎诊断标准，将其分为AI + CP组，AI组。非AI患者分为CP组，健康对照组(H组)。检查并统计四组牙周情况，指标包括牙石指数(CI)、探诊出血指数(BI)、牙周探诊深度(PD)和附着丧失(AL)。统计比较四组口腔健康影响情况量表14 (OHIP-14)评分和龈沟液(gingival crevicular fluid, GCF) IL-6水平。结果：对四组IL-6水平、OHIP-14评分采用单因素方差分析，差异具有统计学意义(IL-6: F = 279.024; OHIP-14: F = 108.806; P P χ2 = 44.432, P χ2 = 19.434, P = 0.022 P P P P P Objective: Exploring the correlation between interleukin-6 and periodontal indicators in patients with anemia of inflammation (AI) and chronic periodontitis (CP). Methods: A total of 142 patients from the Hematology Department, Stomatology Department, and Physical Examination Centers of Chaohu Hospital Affiliated to Anhui Medical University (November 2023~January 2024) were enrolled. AI patients were categorized into AI + CP and AI groups based on CP diagnostic criteria, while non-AI patients were divided into CP and healthy control (H) groups. Periodontal parameters including calculus index (CI), bleeding index (BI), probing depth (PD), and attachment loss (AL) were assessed and recorded across the four groups. Statistical comparison of Oral Health Impact Profile-14 (OHIP-14) scores and gingival crevicular fluid (GCF) IL-6 levels across four groups. Results: Significant differences in IL-6 levels and OHIP-14 scores across the four groups were observed using one-way ANOVA (IL-6: F = 279.024; OHIP-14: F = 108.806; P P χ2 = 44.432, P χ2 = 19.434, P = 0.022 P P P P P < 0.001) .Conclusion: There exists a correlation between chronic periodontitis and anemia of inflammation. Chronic periodontitis is associated with anemia of inflammation. Maintaining oral hygiene and periodontal health is critical for preventing systemic inflammation. GCF IL-6 shows promise as a biomarker for monitoring CP and AI, offering clinical diagnostic value for these conditions.