Evaluation of the effectiveness of autologous mesenchymal stem cells based on titanium nickelide granulesin plasty of a broken vertebral body

Severe compression comminuted and burst fractures of the vertebral bodies require surgical treatment with restoration of the supporting ability of the ventral column. Today, mesenchymal stem cells are also used in the treatment of this type of fractures.Objective of the study: analysis of the results of transpedicular vertebral body plastic surgery with titanium nickelide granules mixed with MSCs.Methods. The study included 102 patients with unstable, uncomplicated fractures of the thoracic and lumbar spine, operated on from the dorsal approach in the Traumatology Department No. 1, National Scientific Center for Traumatology and Orthopedics named after Academician N.D. Batpenov in the period from 2022 to 2023.Results. The study revealed that the method of transpedicular fixation with vertebral body plastic surgery using NiTi granules mixed with MSCs allows eliminating kyphotic spinal deformity, restoring the height of the vertebral body by an average of 94.2±11.2% and leads to a slight loss of correction, while the use of MSCs accelerates bone tissue regeneration and is therapeutically safe when used in traumatology and orthopedics.Conclusions. The use of MSCs accelerates bone tissue regeneration according to the Bridwell bone consolidation criteria and is therapeutically effective and safe when used in traumatology and orthopedics.Keywords: vertebral fracture, mesenchymal stem cells, vertebral body plasty, titanium nickelide.