Temperature-dependence of membrane protein–lipid interactions in membranes
Membrane protein-lipid interactions, like other biomolecular interactions, are often temperature-sensitive. Here, we use variable-temperature electrospray ionization mass spectrometry to investigate the temperature dependence of protein-lipids interactions from membranes. The findings reveal that specific lipid binding, and in some cases metal ion binding, to membrane proteins is significantly enhanced at elevated temperatures.
Authors
- James R. Downing (ORCID: https://orcid.org/0009-0004-4853-7672)
- Smriti Kumar
- Arthur D. Laganowsky (ORCID: https://orcid.org/0000-0001-5012-5547)
- Lauren Stover (ORCID: https://orcid.org/0000-0002-3554-9111)
- David H. Russell (ORCID: https://orcid.org/0000-0003-0830-3914)
- Michael Lynn (ORCID: https://orcid.org/0009-0005-7207-2737)
- Carter Lantz (ORCID: https://orcid.org/0009-0007-1657-8148)
Institutions
- Texas A&M University (US)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01576f
- Citations
- 1
- Primary Topic
- Mass Spectrometry Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 0.76
Funders
- Welch Foundation
- National Institutes of Health