INVESTIGATION OF MEXIDOL AS A PROMISING DRUG FOR PHARMACOLOGICAL CORRECTION OF THE CONSEQUENCES OF PROTON IRRADIATION

Experimental irradiation of rat’s head with protons (2 Gy) showed that mexidol injected at a dose of 150 mg/kg/d during 7 days of exposure and one day after improved considerably cognitive functions in the conditioned response tests (Active avoidance and Open field). Increase of the dose up to 250 mg\kg\d does not retain the effect. We may hypothesize that mexidol at a dose of 150 mg/kg/d compensates significantly the proton-induced changes, whereas a larger dose leads to hypercompensation with some negative manifestations.