Quantitative cervical cord MRI in spinal muscular atrophy: a sensitive imaging biomarker of disease evolution and treatment
Nusinersen showed beneficial effects in both adult and pediatric SMA patients, with more marked improvements in children. Quantitative SC MRI metrics, especially TCA and GM<sub>area</sub>, reflected clinical trends and may serve as non-invasive biomarkers for monitoring treatment effects, pending validation in larger cohorts.
Authors
- Laura Mazzocchi (ORCID: https://orcid.org/0000-0001-7981-1188)
- Anna Pichiecchio (ORCID: https://orcid.org/0000-0002-5654-4088)
- Eduardo Caverzasi (ORCID: https://orcid.org/0000-0002-0350-0460)
- Lisa Maria Farina (ORCID: https://orcid.org/0000-0002-4993-0415)
- Elena Ballante (ORCID: https://orcid.org/0000-0003-3217-8930)
- Claudia A. M. Gandini Wheeler‐Kingshott (ORCID: https://orcid.org/0000-0002-4832-1300)
- Stefano Parravicini (ORCID: https://orcid.org/0000-0003-1509-345X)
- L. Barzaghi
- Giovanni Savini (ORCID: https://orcid.org/0000-0002-7133-429X)
- Niels Bergsland (ORCID: https://orcid.org/0000-0002-7792-0433)
- Carlo Asteggiano (ORCID: https://orcid.org/0000-0002-1439-3293)
- Angela Lucia Berardinelli (ORCID: https://orcid.org/0000-0002-4645-8055)
- Matteo Paoletti (ORCID: https://orcid.org/0000-0002-1221-7747)
- Maria Irene Dainesi
- Alice Gardani
Institutions
- Humanitas University (IT)
- Queen Mary University of London (GB)
- University of Pavia (IT)
- Foundation Center (US)
- IRCCS Humanitas Research Hospital (IT)
- University College London (GB)
- University at Buffalo, State University of New York (US)
Publication Details
- Journal
- Journal of Neurology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1007/s00415-025-13205-x
- Primary Topic
- Neurogenetic and Muscular Disorders Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero della Salute