Endoplasmic Reticulum Stress‐Induced triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Downregulation Exacerbates Platelet Activation and Myocardial Infarction in Patients With Coronary Artery Disease
TREM2 integrates ER stress, immune inflammation, and platelet function. ER stress-induced TREM2 downregulation contributes to platelet hyperactivation in coronary artery disease, suggesting TREM2 activation as a novel therapeutic target.
Authors
- Jianzeng Dong (ORCID: https://orcid.org/0009-0000-8001-7010)
- Haoxuan Zhong (ORCID: https://orcid.org/0000-0001-5038-299X)
- Guanxing Pan
- Y. Guo (ORCID: https://orcid.org/0000-0002-4675-9368)
- Jianjun Zhang (ORCID: https://orcid.org/0000-0001-9689-9898)
- Qian Liu (ORCID: https://orcid.org/0000-0001-8525-7961)
- Ge Zhang (ORCID: https://orcid.org/0000-0002-3116-3246)
- Yangyang Liu (ORCID: https://orcid.org/0000-0001-8296-7095)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-0548-6348)
- Si Zhang (ORCID: https://orcid.org/0000-0002-5682-4995)
- Zhiyong Qi (ORCID: https://orcid.org/0000-0001-5720-4061)
- She Chen (ORCID: https://orcid.org/0000-0002-4077-1649)
- Xiaowen Wu (ORCID: https://orcid.org/0000-0002-4434-7319)
- Hu Hu (ORCID: https://orcid.org/0000-0002-0009-8218)
- Lin Chang (ORCID: https://orcid.org/0000-0003-1878-6155)
- Zhongren Ding (ORCID: https://orcid.org/0000-0001-9487-4865)
- Ruyi Xue
Institutions
- Fujian Medical University (CN)
- Fudan University (CN)
- Tianjin Medical University General Hospital (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
- Zhongshan Hospital (CN)
- Pudong Medical Center (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Huashan Hospital (CN)
- Tianjin Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1161/jaha.124.041220
- Citations
- 3
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 2.39