Unlocking the connection: hemoglobin glycation index as a key driver of bone loss in diabetes-related osteoporosis
This study demonstrates that HGI contributes to bone loss and reduced vertebral BMD by enhancing osteoclast activity. While the impact of HGI on osteoblast function remains unclear, its significant influence on bone resorption highlights its potential role in the pathogenesis of osteoporosis in T2DM patients. These findings offer novel insights into the relationship between diabetes and osteoporosis and suggest that managing HGI levels may provide a therapeutic target for preventing osteoporosis and fractures in T2DM patients.
Authors
- Zhifeng Sheng (ORCID: https://orcid.org/0000-0003-2308-3024)
- Xinpeng Liu (ORCID: https://orcid.org/0000-0002-6484-8268)
- Hong Liu (ORCID: https://orcid.org/0000-0002-1007-6135)
- Wanlin Jin (ORCID: https://orcid.org/0000-0001-6622-9631)
- Zhangxin Wen (ORCID: https://orcid.org/0009-0006-5485-6375)
Institutions
- Central South University (CN)
- Zhuzhou Central Hospital (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fendo.2025.1574064
- Citations
- 1
- Primary Topic
- Bone health and osteoporosis research
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Education Department of Hunan Province
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province