Identification of hub genes in myocardial infarction by bioinformatics and machine learning: insights into inflammation and immune regulation
The five hub genes identified in this study (ANPEP, S100A9, MMP9, DAPK2, and FCAR) significantly contribute to MI development by modulating inflammatory responses and immune regulation. Their strong association with MI pathogenesis highlights their potential as diagnostic markers and therapeutic targets, which may lead to new clinical applications for MI management.
Authors
- Juan Yang (ORCID: https://orcid.org/0000-0001-5028-2227)
- Xiang Li (ORCID: https://orcid.org/0000-0003-0671-7160)
- Jun Zhang (ORCID: https://orcid.org/0000-0002-8760-6747)
- Li Ma (ORCID: https://orcid.org/0000-0002-5444-5262)
Institutions
- Shanghai Tenth People's Hospital (CN)
- Chongqing Dazu District People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Molecular Biosciences
- Published
- 2025-06-24
- DOI
- https://doi.org/10.3389/fmolb.2025.1607096
- Citations
- 3
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 4.16