Pancreaticoduodenal resection with venous resection: experience of a high-profile center in Ukraine

Aim - to evaluate the feasibility and safety of venous resections (VR) during pancreatoduodenectomy (PD) in patients with malignant tumors of the periampullary region. Materials and methods. A retrospective cohort study was conducted, including 111 patients who underwent PD for malignant tumors of the periampullary region between 2018 and 2023. Patients were divided into two groups: with and without VR. Statistical analysis was performed to compare mean values and assess postoperative complications using the Clavien-Dindo classification. Results. Mean blood loss, operative time, rates of complications, delayed gastric emptying, postoperative pancreatic fistula, hospital and 30-day mortality did not differ significantly between the groups. Median overall survival was 22 months in the VR group and 37 months in the non-VR group; the 5-year survival rates were 22.2% and 35.9%, respectively. Conclusions. PD with VR is a safe and feasible procedure for patients with tumor invasion of major veins. The inclusion of VR does not significantly increase risks or worsen postoperative outcomes. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee for all participants. The informed consent of the patients was obtained for the study. The authors declare no conflict of interest.