Functional characterization of transcriptional enhancers in an Anopheles genetic locus controlling natural resistance to the malaria parasite, Plasmodium falciparum
Despite the absence of an ENH_2L-03 effect on infection outcome, multiple enhancers can cooperate to influence a phenotype, and further examination of this enhancer is warranted. Overall, we provide a pipeline for the in vivo functional study of transcriptional enhancers in Anopheles, towards understanding how enhancer function may control important vector phenotypes.
Authors
- Cameron E. Anderson
- Adrien Pain (ORCID: https://orcid.org/0000-0003-0467-1357)
- Christian Mitri (ORCID: https://orcid.org/0000-0003-3882-2029)
- Emma Brito‐Fravallo
- Michelle M. Riehle (ORCID: https://orcid.org/0000-0003-1042-1653)
- Kenneth D. Vernick (ORCID: https://orcid.org/0000-0003-4336-312X)
- Renée Zakhia
- Natalia Marta Zmarlak-Feher
- Kathryn S Taquet
Institutions
- Institut Pasteur (FR)
- Medical College of Wisconsin (US)
- Université Paris Cité (FR)
Publication Details
- Journal
- Epigenetics & Chromatin
- Published
- 2025-06-24
- DOI
- https://doi.org/10.1186/s13072-025-00597-3
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- European Commission
- Agence Nationale de la Recherche
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases