ACOT4 and ACOT6 activate Akt-mTOR pathway and inhibit calcium oxalate-induced renal tubular cell injury
ACOT4 and ACOT6 could be protecting factors for kidney cell injury induced by CaOx via reducing apoptosis and activating Akt/mTOR signaling pathway. The study of the role of ACOT4 and ACOT6 in kidney cell injury provides a new insight into the cause of CaOx kidney stone formation. Its in-depth study may provide new targets for stone treatment.
Authors
- Shenghan Wang
- Qiang Gao (ORCID: https://orcid.org/0000-0001-7571-4903)
- Yuqiang Shi
- Zhentao Lei
- Sherryn Sherryn
- Bao Zhang (ORCID: https://orcid.org/0000-0003-1563-7103)
- Wei Liu (ORCID: https://orcid.org/0000-0002-5739-9986)
Institutions
- Peking University (CN)
- Aerospace Center Hospital (CN)
- Indonesia Defense University (ID)
Publication Details
- Journal
- Kidney & Blood Pressure Research
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1159/000546897
- Primary Topic
- Kidney Stones and Urolithiasis Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00