Exercise-induced Metabolite N-lactoyl-phenylalanine Ameliorates Colitis by Inhibiting M1 Macrophage Polarization via the Suppression of the NF-κB Signaling Pathway
Our results suggest that exercise can induce the production of Lac-Phe, which plays a preventive role against dextran sulfate sodium-induced colitis in mice. Lac-Phe mitigates colitis through inhibition of the polarization of M1 macrophage. Adjusting macrophage polarization with Lac-Phe and phenylalanine supplementation may offer a potential therapeutic strategy for managing IBD.
Authors
- Haoxian Ke (ORCID: https://orcid.org/0000-0003-0837-8174)
- Ping Lan (ORCID: https://orcid.org/0000-0002-8901-8498)
- Ming Yuan (ORCID: https://orcid.org/0000-0001-5295-0129)
- Shubiao Ye (ORCID: https://orcid.org/0000-0002-4203-4546)
- Jiaqi Liu (ORCID: https://orcid.org/0000-0002-6050-8944)
- Guanzhan Liang
- Tuo Hu (ORCID: https://orcid.org/0000-0001-7069-1466)
- Junfeng Huang (ORCID: https://orcid.org/0000-0002-1672-3751)
- Xianrui Wu (ORCID: https://orcid.org/0000-0002-4743-7133)
- Chi Zhang (ORCID: https://orcid.org/0009-0001-8360-3696)
- Shaopeng Chen (ORCID: https://orcid.org/0000-0002-3632-9727)
- Xiaosheng He (ORCID: https://orcid.org/0000-0002-9441-4153)
- Runfeng Yu
Institutions
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101558
- Citations
- 11
- Primary Topic
- Exercise and Physiological Responses
- Type
- article
- Field-Weighted Citation Impact
- 11.29
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China Stem Cell and Translational Research
- Basic and Applied Basic Research Foundation of Guangdong Province