Phosphocreatine Rescues Intestinal Epithelial Metabolic Dysfunction Related to Creatine Kinase Loss and Is Protective in Murine Colitis
Loss of CK, a change that occurs in inflammatory bowel disease, causes defective energy metabolism and IEC functioning. PCr supplementation rescues many detrimental effects of CK loss and serves as a protective mechanism in murine colitis. These findings may provide insight into pathogenic mechanisms and a novel therapeutic modality in inflammatory bowel disease.
Authors
- J. Scott Lee (ORCID: https://orcid.org/0000-0001-7151-9828)
- Caroline Hall (ORCID: https://orcid.org/0000-0002-7100-3423)
- Geetha Bhagavatula (ORCID: https://orcid.org/0000-0002-4716-4892)
- Sean P. Colgan (ORCID: https://orcid.org/0000-0003-0431-8887)
- Ian M. Cartwright (ORCID: https://orcid.org/0000-0003-3430-0143)
- Rane M. Neuhart
- Corey S. Worledge
- Emily Murphy (ORCID: https://orcid.org/0009-0000-3181-7994)
- Ciara Schaepe
Institutions
- University of Colorado Hospital (US)
- Children's Hospital Colorado (US)
- Rocky Mountain MS Center (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101557
- Citations
- 2
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 2.33
Funders
- U.S. Department of Veterans Affairs
- Crohn's and Colitis Foundation of America
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Advancing Translational Sciences