Research Progress on the Treatment of Diabetic Nephropathy by Traditional Chinese Medicine through Regulating the AMPK Signaling Pathway

糖尿病肾病(Diabetic Nephropathy DN)是糖尿病最常见的并发症之一，也是终末期肾病的主要原因。有大量研究表明，DN与AMP活化蛋白激酶(AMPK)信号通路之间有密切的关系，AMPK信号通路通过与细胞自噬、氧化应激和炎症反应等相互作用影响DN的进展。中医药在DN的临床治疗中起到重要作用，且中医药基于该机制防治DN的研究已取得较大进展。因此笔者从AMPK信号通路出发，阐述其干预DN的关键机制和相关研究进展，整理了基于该信号通路的中药单体活性成分或提取物、中药复方治疗DN的方法，以期为中医药治疗DN提供更多帮助。Diabetic Nephropathy, a common complication of diabetes, is a major cause of end-stage renal disease. Ample research indicates a close link between DN and the AMP-activated protein kinase signaling pathway, which impacts DN progression through regulating autophagy, oxidative stress, and inflammation. Traditional Chinese medicine is crucial in DN treatment, with significant progress in relevant prevention and treatment research. This paper reviews the key mechanisms of the AMPK pathway in DN intervention, and summarizes the application of traditional Chinese medicine monomers, extracts, and compound formulas for DN treatment, aiming to inform traditional Chinese medicine treatment of DN.