Comparative study of the microbiological activity of pazufloxacin, levofloxacin and moxifloxacin

Introduction. Increasing antibiotic resistance is an important global problem. One of the most common classes of antibacterial drugs used in therapeutic practice are fluoroquinolones. Such drugs as levofloxacin, moxifloxacin, and pazufloxacin are the most promising for the treatment of a wide range of infections. Pazufloxacin has a good clinical effect in the treatment of infections resistant to other antibiotics. With respect to levofloxacin and moxifloxacin, there are criteria for determining sensitivity and significant experience in clinical and microbiological studies indicating their effectiveness, but with respect to pazufloxacin, there are few such studies and currently there are no criteria for interpreting the diameters of growth retardation zones and/or indicators of the values of the minimum suppressive concentration (MSC). Aim. To evaluate the distribution of the values of the minimum suppressive concentrations of drugs of the fluoroquinolone group: pazufloxacin, levofloxacin, moxifloxacin in relation to 200 clinical isolates of microorganisms. Materials and methods. We selected 200 bacterial strains isolated from patients from various regions of the Russian Federation. Among them are 20 strains of Pseudomonas aeruginosa , excluding MBL producers, 20 – Klebsiella pneumoniae , excluding MBL producers, 20 – Streptococcus pneumoniae , 20 – Enterococcus faecalis , 20 – Enterococcus faecium , 20 – Escherichia coli , excluding MBL producers, 20 – Proteus spp ., excluding MBL producers, 20 – Staphylococcus aureus , including MRSA, 20 – Haemophilus influenzae , 20 – Moraxella catarrhalis . Results and discussion. According to the data obtained, it was found that some of the studied strains have a high level of sensitivity to the drugs levofloxacin and moxifloxacin, and some, on the contrary, retain a high level of resistance. The criteria for evaluating the MSC of pazufloxacin in relation to the studied isolates have not been determined, but it is worth noting that most cultures have demonstrated an achievable value of MSC indicators. This suggests a high level of efficacy of the drug in clinical use. Conclusions. According to the results of the study, sensitivity to low values of pazufloxacin was revealed in relation to a number of cultures, in the absence of sensitivity to other drugs of the fluoroquinolone group, this also indicates the absence of crossresistance with drugs of this group.