The quality of life indicators in patients with chronic obstructive pulmonary disease after PCV vaccination: A posteriori analysis of 10-year follow-up

Introduction. The natural course of chronic obstructive pulmonary disease (COPD) is characterized by an exacerbation of symptoms and a decrease in quality of life (QOL). QOL is a complex indicator for assessing people’s health and well-being, which is influenced by many factors. Health-related QOL assessment tools are widely used to determine physical, functional, social, and psychosocial well-being from a patient’s perspective. Low QOL levels are common among patients with COPD, especially in the late stages. In 2023, the results of a 10-year evaluation of the effectiveness of vaccine prophylaxis against pneumococcal infection were published, but they did not include a QOL analysis. Aim. To conduct a posteriori analysis of the assessment of QOL over 10 years of follow-up in patients with COPD vaccinated with conjugated pneumococcal vaccine Prevenar 13 (PCV13). Materials and methods. The study included a total of 362 male patients who were treated or monitored at the Chelyabinsk Regional Pulmonological Center in 2012–2022. The 13-valent conjugated pneumococcal vaccine Preventar-13 was used for vaccine prophylaxis. The QOL assessment was conducted using two questionnaires: the Russian-language version of the St. George Hospital Questionnaire (SGRQ), and the universal CAT questionnaire. Results. The indicators of the SGRQ questionnaire scales in the studied groups did not significantly differ (p > 0.05). A year after the start of the observation, changes in QOL were detected on all scales of the questionnaire, while maintaining statistically significant changes over the 10 years of observation. In the observation group of unvaccinated patients, there was no clinically or statistically significant change in QOL parameters according to all criteria. A similar dynamic was demonstrated by the indicator of the СAT questionnaire. Conclusions. Vaccine prophylaxis with pneumococcal vaccines has a significant positive effect on the QOL of patients with COPD, at least in the 10-year follow-up period. The use of QOL questionnaires makes it possible to focus on the correctness of the chosen treatment tactics both in the early and long-term periods of follow-up of patients with COPD. The use of PCV13 for the vaccination of COPD patients reliably minimizes the number of exacerbations requiring outpatient and hospital treatment, reduces the number of episodes of pneumonia as much as possible, and reduces the cost of the healthcare system to combat this nosology.