The Mycology Profile in Immunocompromised Patients of CHU Mohammed VI of Marrakech

Introduction: This Moroccan study focuses on fungal infections in immunocompromised patients, a particularly vulnerable population. Conducted over two years at CHU Mohamed VI in Marrakech, the research involved 271 patients with various forms of immunosuppression. Result: The results reveal that Candida spp. led the identified pathogens, accounting for 39.5% of cases, with a predominance of Candida albicans (56%). Dermatophytes occupy the second position (24%), followed by Aspergillus spp. (8.5%). Notably, researchers observed a worrying resistance to fluconazole in 28% of cases, while amphotericin B retains excellent efficacy (98% sensitivity). Discussion: The detailed analysis shows distinct profiles according to the underlying pathologies : HIV patients mainly present candidiasis, diabetics develop dermatophyte infections, and cases of mucormycosis occur exclusively in the latter population. The most concerned departments are those of infectious diseases, dermatology and hematology. These findings highlight several key issues. On the one hand, early diagnosis requires more sophisticated techniques such as molecular biology. On the other hand, therapeutic management must adapt to the emergence of resistance to common antifungal agents. The authors emphasize the importance of close collaboration between different specialists to optimize the management of these serious infections. Conclusion: This research provides valuable data for the Moroccan and African context, while confirming some trends observed on a global scale. It also opens up avenues for improving diagnostic and treatment strategies in hospital settings.