Calcium(<scp>ii</scp>)-catalyzed [2+3] annulation of enynones: a sustainable approach to 9<i>H</i>-pyrrolo[1,2-<i>a</i>]indole frameworks
A Ca(II)-catalyzed, atom-economic, and regioselective [2+3] annulation reaction has been developed to synthesize 9<i>H</i>-pyrrolo[1,2-<i>a</i>]indoles by using easily accessible tryptamines and enynones. This protocol exhibits broad functional group tolerance; thus, 9<i>H</i>-pyrrolo[1,2-<i>a</i>]indole frameworks with diverse substitution patterns can be synthesized. The synthetic utility of this method is further demonstrated through its effectiveness in gram-scale preparations and versatile synthetic transformations.
Authors
- Kyeong Lee (ORCID: https://orcid.org/0000-0002-5455-9956)
- Jong Yeon Hwang (ORCID: https://orcid.org/0000-0001-5926-4877)
- Ashok Kale (ORCID: https://orcid.org/0000-0002-3690-3741)
- Jong-Hyuk Kim
- Yongseok Choi (ORCID: https://orcid.org/0000-0002-3622-3439)
- Shubham C Rivonker
Institutions
- Korea University (KR)
- Dongguk University (KR)
- Korea Research Institute of Chemical Technology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc02204e
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00