Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction

Hispidulin ameliorated disease manifestations in a DRCD-induced murine model, attenuating neuroinflammation and histopathological damage in hippocampal tissues through gut microbiota modulation.

Authors

Institutions

Publication Details

Journal
Frontiers in Pharmacology
Published
2025-06-20
DOI
https://doi.org/10.3389/fphar.2025.1601689
Citations
2
Primary Topic
Medicinal Plants and Bioactive Compounds
Type
article
Field-Weighted Citation Impact
1.61

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction

Zhixuan Huang, Yangwen Ai, Jian Li, Hui Li et al.
2 citations
Frontiers in Pharmacology
Medicinal Plants and Bioactive Compounds
1.61
article

Network pharmacology-based prediction and “gut microbiota-inflammation-brain axis” validation of the active ingredients and potential mechanisms of Plantagins Herba for treating diabetes-related cognitive dysfunction

Zhixuan Huang, Yangwen Ai, Jian Li, Hui Li, Dongyue Zhou
article en
2 citations

Abstract

Hispidulin ameliorated disease manifestations in a DRCD-induced murine model, attenuating neuroinflammation and histopathological damage in hippocampal tissues through gut microbiota modulation.

Frontiers in PharmacologyVol. 16
Jiangxi University of Traditional Chinese Medicine (CN), Chinese Academy of Medical Sciences & Peking Union Medical College (CN), China Academy of Chinese Medical Sciences (CN)
Natural Science Foundation of Jiangxi Province
Good health and well-being
Openalex Percentile: Top 16%
Medicinal Plants and Bioactive Compounds
1.61
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.