Decreased Excitability and Voltage‐Gated Sodium Currents in Myenteric Neurons Contribute to the Impairment of Gut Contraction in Type 2 Diabetes Mice
The decreased excitability and downregulation of total voltage-gated sodium currents in the myenteric neurons of type 2 diabetic mice could partially explain the cellular mechanisms underlying the colonic dysmotility observed in patients with diabetes. Targeting voltage-gated sodium channels may represent a novel therapeutic approach for modulating diabetic intestinal dysfunction.
Authors
- Eduardo E. Valdez-Moráles (ORCID: https://orcid.org/0000-0003-3736-7626)
- Andrómeda Liñán‐Rico (ORCID: https://orcid.org/0000-0001-8370-7316)
- Alma Barajas‐Espinosa (ORCID: https://orcid.org/0000-0002-3961-3280)
- Fernando Ochoa‐Cortés (ORCID: https://orcid.org/0000-0002-1559-8012)
- Raquel Guerrero‐Alba (ORCID: https://orcid.org/0000-0001-6010-1012)
- Guillermo A. Cabral‐García
- Estefanía G. Contreras‐Vázquez
Institutions
- Universidad Autónoma del Estado de Hidalgo (MX)
- Autonomous University of Aguascalientes (MX)
- Secretaría de Ciencia Tecnología e Innovación (MX)
- Universidad de Colima (MX)
Publication Details
- Journal
- Neurogastroenterology & Motility
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1111/nmo.70105
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00