Heterogeneity and co-occurrence of resistance mechanisms in EGFR-TKI-induced NSCLC to SCLC transformation: a case report
Confirming SCLC transformation from a single site alone through biopsy may not provide a comprehensive understanding of the resistance mechanisms underlying progression at all sites. This highlights the significance of combined treatment strategies, particularly with LCT, for heterogeneous tumors in SCLC transformation.
Authors
- Ke Xu (ORCID: https://orcid.org/0009-0004-0512-785X)
- Juan Wang (ORCID: https://orcid.org/0000-0003-1305-190X)
- Xiaoli Liu (ORCID: https://orcid.org/0000-0002-2585-7559)
- Lijuan Zhang (ORCID: https://orcid.org/0000-0003-0814-4925)
- Hongtao Zhang (ORCID: https://orcid.org/0000-0002-1572-0719)
- Guohui Cao
Institutions
- Hebei General Hospital (CN)
Publication Details
- Journal
- AME Case Reports
- Published
- 2025-06-22
- DOI
- https://doi.org/10.21037/acr-24-67
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00