Nicotine-induced PD-L1 expression in lung squamous cell carcinoma is mediated by the α7-nAChR/STAT3 signaling pathway
α7-nAChR and its encoding gene <i>CHRNA7</i> are upregulated in LUSC tissue and are associated with smoking status. Patients with high expression of <i>CHRNA7</i> have a relatively worse prognosis. Nicotine may upregulate PD-L1 expression in LUSC through the α7-nAChR/STAT3 pathway.
Authors
- Ce Zhou
- Ning Wang (ORCID: https://orcid.org/0009-0006-0180-8361)
- Wenting Wang (ORCID: https://orcid.org/0000-0002-8344-0102)
- Yixuan Wang (ORCID: https://orcid.org/0000-0002-0014-4050)
- Yinan Li (ORCID: https://orcid.org/0000-0001-8934-9361)
- Yaoyao Wang (ORCID: https://orcid.org/0000-0002-2250-0378)
- Xin Zou (ORCID: https://orcid.org/0000-0003-4771-3836)
Institutions
- Qingdao University (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Translational Cancer Research
- Published
- 2025-06-22
- DOI
- https://doi.org/10.21037/tcr-2024-2587
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14