Procoagulant effect of phosphatidylserine-exposed blood cells, endothelial cells and extracellular vesicles in patients with aortic stenosis
Our study revealed a previously unrecognized association between exposed PS levels on blood cells, ECs and EVs and PCA in AS. Lactadherin promises to be a new therapy by blocking PS to prevent thrombosis in AS patients.
Authors
- Jihe Li (ORCID: https://orcid.org/0000-0003-4961-2182)
- Yujie Zhou (ORCID: https://orcid.org/0000-0002-6740-9818)
- Dongxia Tong
- Fangyu Xie (ORCID: https://orcid.org/0000-0003-3264-9325)
- Haiyang Wang (ORCID: https://orcid.org/0000-0001-6148-4924)
- Zhaona Du
- Wei Wu (ORCID: https://orcid.org/0000-0002-1541-333X)
- Wei Xia
- Yibing Shao (ORCID: https://orcid.org/0000-0002-2024-6943)
Institutions
- Qingdao University (CN)
- Beijing Anzhen Hospital (CN)
- Qingdao Municipal Hospital (CN)
Publication Details
- Journal
- Thrombosis Journal
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1186/s12959-025-00755-3
- Citations
- 3
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 2.39
Funders
- Beijing Municipal Administration of Hospitals
- National Key Research and Development Program of China