Investigation of The Effect of 25(OH)D3 Levels on the Disease Severity and the Course of the Treatment in Active Pulmonary Tuberculosis Patients

Background and Aim: Emerging evidence suggests a link between vitamin D deficiency and increased susceptibility to TB. Vitamin D regulates calcium, phosphorus, and bone metabolism and plays a pivotal role in immune responses. This study investigates the relationship between 25(OH)D3 levels and the clinical course, radiological findings, and treatment outcomes in TB patients. Materials and Methods: This prospective study was conducted over ten months at a tertiary care hospital, involving 70 newly diagnosed TB patients (aged 18-69 years) and 20 healthy controls. TB diagnosis was confirmed through clinical, radiological, and microbiological findings, including acid-resistant bacteria (ARB) smear and M. tuberculosis culture positivity. All participants underwent physical examinations, routine blood tests, and serum 25(OH)D3 level measurements. Serum 25(OH)D3 levels were categorized as deficient (