Anti-Obesity Properties of Binahong (Anredera Cordifolia) Extract on Hepatic Steatosis in Wistar Rats Model

Obesity, characterized by the accumulation of adipocytes, is associated with complications such as fatty liver and non-alcoholic steatosis, which can be fatal. This research investigates the properties use of Anredera cordifolia ethanol extract in reducing steatosis through microscopic analysis of the non-alcoholic fatty liver disease activity scores (NAS) and immunohistochemical examination (IRS) of PPARγ expression in hepatic cells and abdominal fat tissue in obese Wistar rats .Significant differences were observed in overall steatosis scores among groups (p < 0.005), with the control group (K1) exhibiting markedly higher scores compared to all treatment groups (P50, P100, P150; P < 0.005). Additionally, significant differences in NAS scores were found between the K1 and K2 groups (P < 0.05), as well as among the K0 and K1 groups (P < 0.05). A significant difference in PPARγ IRS was noted between K0 and K2 groups and all treatment groups (P50, P100, P150; P < 0.05). Similarly, a significant difference was observed among the K2 group and all treatment groups (P < 0.05), as well as among the K1 and a higher-dose treatment group (P100, P150). Beyond reducing abdominal circumference and adipose tissue in the abdomen, the anti-obesity effect of A. cordifolia extract was evident in reducing hepatic steatosis, potentially mediated through the downregulation of PPARγ expression.