OS IMPACTOS DA TOXOPLASMOSE EM PACIENTES E SEU ACOMETIMENTO OCULAR

ABSTRACT Introduction: Toxoplasmosis is caused by the parasite Toxoplasma gondii, affecting especially children and immunocompromised individuals. Globally widespread, this infection is prevalent in tropical climates, affecting up to 80% of the population in South America, including Brazil. Objective: To analyze current literature related to the impacts caused in patients affected by toxoplasmosis with ocular sequelae, in order to contribute to the advancement of the theoretical scope of the area. Materials and Methods: The present study will consist of a systematic literature review on the impacts of toxoplasmosis in patients and its ocular involvement. The research will be based on the methodological guide by Souza, Silva, and Carvalho (2010), which outlines six phases for conducting an integrative review: formulation of the guiding question, literature search, data collection, critical analysis of studies, discussion of results, and presentation of the review. The study will include experimental and non-experimental studies, such as clinical trials, qualitative studies, and theoretical reviews, to provide a holistic understanding of the impacts of toxoplasmosis, with an emphasis on ocular involvement.. Expected Results: The work aims to review the literature on the impacts of toxoplasmosis with ocular sequelae in patients, addressing clinical manifestations such as chorioretinitis and vision loss, as well as psychological and social impacts. It is expected to identify gaps in research, propose improvements in diagnosis and treatment, and develop evidence-based guidelines. Recommendations include new areas of study, collaboration between research centers, and evaluation of new therapies. Public education and awareness are also goals, with the creation of educational materials and campaigns. The study seeks to integrate knowledge from various fields for a holistic understanding of the impacts and advances in the management of ocular toxoplasmosis. Keywords: Toxoplasmosis; Toxoplasma gondii; Parasitic infection; Immune system.