Inflammation-related gene ITGA5 affects the healing of diabetic foot ulcers through PI3K-AKT signaling pathway
ITGA5 drives DFU pathogenesis through suppression of PI3K-AKT signaling under hyperglycemia. Targeting ITGA5 may offer a therapeutic strategy to enhance wound healing, highlighting its potential as a diagnostic and therapeutic biomarker for DFU.
Authors
- Lujia Mao
- Xin Zhou (ORCID: https://orcid.org/0000-0002-8667-0309)
- Ronghua Yang (ORCID: https://orcid.org/0000-0002-9685-7003)
- Xuehua Wang (ORCID: https://orcid.org/0000-0003-1324-1471)
- Yongjian Chen (ORCID: https://orcid.org/0000-0002-6784-4828)
- Jianwei Chen (ORCID: https://orcid.org/0000-0003-2332-4609)
- Xiaoxiang Wang (ORCID: https://orcid.org/0009-0006-2653-3982)
- Weiqiang Zhang (ORCID: https://orcid.org/0009-0001-5885-5613)
- Sitong Zhou (ORCID: https://orcid.org/0000-0003-2082-742X)
Institutions
- Sun Yat-sen University (CN)
- Guangdong Medical College (CN)
- First People's Hospital of Foshan (CN)
- Guangzhou First People's Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Guangdong Provincial People's Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- European Journal of Pharmacology
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1016/j.ejphar.2025.177865
- Citations
- 1
- Primary Topic
- Diabetic Foot Ulcer Assessment and Management
- Type
- article
- Field-Weighted Citation Impact
- 1.29