Identification and characterization of survival-dependent genes in esophageal cancer via the DepMap database: unraveling their association with immune infiltration
This study establishes a four-gene survival signature for esophageal cancer that distinguishes high-risk from low-risk populations, providing novel prognostic indicators. Immune response pathways were downregulated in high-risk patients, offering potential targets for understanding esophageal cancer mechanisms and developing immunotherapeutic strategies.
Authors
- Jian He (ORCID: https://orcid.org/0000-0002-1426-7799)
- Xiuzhong Yao (ORCID: https://orcid.org/0000-0002-4856-0985)
- L. Chen
- Fangzhu Xiao (ORCID: https://orcid.org/0000-0003-1177-9219)
- Wentao Xiao
Institutions
- Nantong University (CN)
- Affiliated Hospital of Nantong University (CN)
- First Affiliated Hospital of University of South China (CN)
- Xiangnan University (CN)
- University of South China (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1007/s12672-025-02942-0
- Citations
- 1
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.01