Notch3 enhances the synergistic effect of all-trans retinoic acid and calcipotriol in pancreatic stellate cell activation
Notch3 is a target for inhibiting PSC activation, ATRA and calcipotriol regulate Notch3 expression in PSCs, and targeting Notch3 in combination with ATRA and calcipotriol against PSC activation holds promise as a novel therapeutic approach for treating pancreatic fibrosis in CP.
Authors
- Weihong Du (ORCID: https://orcid.org/0000-0001-9538-952X)
- Yu-xiang Zhang (ORCID: https://orcid.org/0000-0002-0249-0993)
- Zheng Lian (ORCID: https://orcid.org/0000-0002-1672-3364)
- Paizi-Guli Tusup-Han
Institutions
- Capital Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-06-22
- DOI
- https://doi.org/10.1186/s12967-025-06666-1
- Citations
- 1
- Primary Topic
- Pancreatic function and diabetes
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Beijing Municipality