Exploring the causal relationship between CX3CL1 and prostate cancer prognosis using Mendelian randomization

This study demonstrated that genetically predicted CX3CL1 levels are inversely associated with PCa risk. Further analysis using public databases showed that reduced CX3CL1 expression in PCa cells is associated with lower immune cell infiltration, which may contribute to poorer prognosis. These findings suggest that CX3CL1 may serve as a potential biomarker for predicting PCa risk and patient outcomes and that immunotherapy strategies targeting CX3CL1 could offer therapeutic benefits for PCa patients.