Simulation Study of Methyl Salicylate Production via Reactive Distillation Columns

In this research, reactive distillation column simulation of methyl salicylate (MeSC) synthesis is well explored and discussed. Methyl salicylate is one of the common esters used in industries such as the manufacture of pharmaceuticals, fragrances and flavors and is produced through esterification of salicylic acid (ScA) and methanol (MeOH). Reactive distillation, which combines the reaction kinetics and separation operations together in the same vessel, can be regarded as a very effective approach. By Applying different parameters using the process simulation software, the best operating conditions for the formation of methyl salicylate were determined including the temperature and the types of columns. Here research is carried out with an aim of assessing the performances of batch (CBD) and semi batch (SBD) processes of reactive distillation and establish the conversion rates as well as the conversion efficiencies. The accomplishment of the production process simulation is facilitated by gPROMS Module Builder that can model more than simple reactions to produce high purity methyl salicylate through distillation. The paper also compares the efficiency of the SBD composition with the CBD methods, and the statistics differ significantly; the SBD composition has a 85% conversion rate and has the highest purity of 99%. Insights from simulation provide valuable guidance for optimizing process parameters and selecting the most appropriate distillation mode for industrial-scale production. This research contributes to ongoing efforts to intensify the process and emphasizes the potential of reactive distillation as aviable method for methyl salicylate synthesis.