Rapid and specific immunoPET imaging of Nectin-4 in gastric cancer and non-small cell lung cancer using [64Cu]Cu-NOTA-EV-F(ab’)2
[<sup>64</sup>Cu]Cu-NOTA-EV-F(ab')<sub>2</sub> offers rapid, specific, and high-contrast immunoPET imaging of Nectin-4-expressing tumors in GC and NSCLC models, highlighting its potential as a non-invasive diagnostic tool for Nectin-4-targeted cancer imaging.
Authors
- Tianyao Wang (ORCID: https://orcid.org/0000-0002-9349-8930)
- Molly C. DeLuca
- Jonathan W. Engle (ORCID: https://orcid.org/0000-0002-3399-7228)
- Xinyao Sun
- Weibo Cai (ORCID: https://orcid.org/0000-0003-4641-0833)
- Jessica C. Hsu (ORCID: https://orcid.org/0000-0002-3599-2834)
- Lei Kang (ORCID: https://orcid.org/0000-0001-8729-4547)
- Liming Li (ORCID: https://orcid.org/0009-0006-7408-7761)
- Xiaoyan Li (ORCID: https://orcid.org/0000-0003-1910-2464)
- Jun Lü (ORCID: https://orcid.org/0000-0002-7343-9706)
- Wenpeng Huang (ORCID: https://orcid.org/0000-0001-7405-3816)
- Yongkang Qiu
Institutions
- University of Wisconsin–Madison (US)
- University of Auckland (NZ)
- Peking University (CN)
- Yangtze River Delta Physics Research Center (China) (CN)
- Peking University First Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- European Journal of Nuclear Medicine and Molecular Imaging
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1007/s00259-025-07402-z
- Citations
- 5
- Primary Topic
- Peptidase Inhibition and Analysis
- Type
- article
- Field-Weighted Citation Impact
- 5.23
Funders
- National Natural Science Foundation of China
- Beijing Municipal Science and Technology Commission
- Beijing Nova Program