Isotope dilution-liquid chromatography-tandem mass spectrometry-based candidate reference measurement procedures for the quantification of total and free phenytoin in human serum and plasma
We present a novel LC-MS/MS-based RMP for phenytoin in human serum and plasma that provides a traceable and reliable platform for the standardization of routine assays and evaluation of clinically relevant samples.
Authors
- Friederike Bauland
- Judith Taibon
- Christian Geletneky
- Christoph Seger (ORCID: https://orcid.org/0000-0002-3984-461X)
- N. S. Singh (ORCID: https://orcid.org/0000-0003-2883-6726)
- Lorenz Risch (ORCID: https://orcid.org/0000-0003-2692-6699)
- Janik Wild
- Linda Salzmann
- C. Schäfer (ORCID: https://orcid.org/0009-0001-2705-9382)
- Tobias Schierscher
- Andrea Geistanger (ORCID: https://orcid.org/0000-0002-5105-6026)
- M. Seitz
Institutions
- Roche Pharma AG (Germany) (DE)
- Labormedizinische Zentrum Dr Risch (Switzerland) (CH)
Publication Details
- Journal
- Clinical Chemistry and Laboratory Medicine (CCLM)
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1515/cclm-2024-0858
- Citations
- 1
- Primary Topic
- Pharmacological Effects and Toxicity Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.49