Metabolic consequences of altered kidney glucose reabsorption under normoglycemic conditions
KPTC-GLUT2 plays a previously unrecognized role in regulating renal and systemic energy metabolism. Its deletion induces a systemic energy-conserving phenotype driven by kidney-intrinsic changes, highlighting the kidney's contribution to whole-body metabolic homeostasis beyond glucose filtration.
Authors
- Gil Leibowitz (ORCID: https://orcid.org/0000-0002-6915-4361)
- Ori Shalev (ORCID: https://orcid.org/0000-0002-1628-834X)
- Bella Agranovich
- Saja Baraghithy (ORCID: https://orcid.org/0000-0003-1526-7173)
- Narottam Prasad Sahu (ORCID: https://orcid.org/0000-0003-3932-7302)
- Liad Hinden (ORCID: https://orcid.org/0000-0002-0307-4350)
- Alina Nemirovski (ORCID: https://orcid.org/0000-0002-2598-0119)
- Joseph Tam (ORCID: https://orcid.org/0000-0002-0948-0093)
- Aviram Kogot‐Levin (ORCID: https://orcid.org/0000-0001-7492-4466)
- Majdoleen Ahmad (ORCID: https://orcid.org/0000-0001-6893-6508)
- Ifat Abramovich (ORCID: https://orcid.org/0009-0009-8760-6630)
- Rinat Abramovitch (ORCID: https://orcid.org/0000-0003-1126-7467)
- Eyal Gottlieb (ORCID: https://orcid.org/0000-0002-9770-0956)
- Anna Permyakova (ORCID: https://orcid.org/0000-0003-3016-050X)
Institutions
- Technion – Israel Institute of Technology (IL)
- Hebrew University of Jerusalem (IL)
- Hadassah Medical Center (IL)
- Rappaport Family Institute for Research in the Medical Sciences (IL)
Publication Details
- Journal
- Molecular Metabolism
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1016/j.molmet.2025.102192
- Citations
- 1
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Juvenile Diabetes Research Foundation United States of America
- Israel Science Foundation