The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D

This is the first study to indirectly elicit utility values in APDS through valuation by the general population and clinical experts. This expands on the current literature for APDS by providing an overview of how HRQoL declines with disease progression and increasing number of manifestations.

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Publication Details

Journal
Advances in Therapy
Published
2025-06-21
DOI
https://doi.org/10.1007/s12325-025-03252-1
Primary Topic
Immunodeficiency and Autoimmune Disorders
Type
article
Field-Weighted Citation Impact
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article

The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D

Ashley Enstone, Robin Wyn, Joanne B Tutein Nolthenius, John Whalen et al.
Advances in Therapy
Immunodeficiency and Autoimmune Disorders
article

The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D

Ashley Enstone, Robin Wyn, Joanne B Tutein Nolthenius, John Whalen, Annabel Griffiths, Olivia Dodd
article en

Abstract

This is the first study to indirectly elicit utility values in APDS through valuation by the general population and clinical experts. This expands on the current literature for APDS by providing an overview of how HRQoL declines with disease progression and increasing number of manifestations.

Advances in TherapyVol. 42(8)
Adelphi Group (United Kingdom) (GB), Pharming Group (Netherlands) (NL), Costello Medical Consulting (United Kingdom) (GB)
Decent work and economic growth
Openalex Percentile: Top 84%
Immunodeficiency and Autoimmune Disorders
DOIOpen Access PDFOpenAlex
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The Impact of Activated Phosphoinositide 3-Kinase δ Syndrome (APDS) on Health-Related Quality of Life (HRQoL): Elicitation of Health State Utility Values Through Time Trade-Off (TTO) and EQ-5D — Ashley Enstone, Robin Wyn, et al. · Advances in Therapy (2025) | TGRS Research Map | TGRS