Development of Propyl Paraben-Loaded Microsponge for Enhanced Preservation in Skin Creams

This study emphasizes developing a microsponge-based delivery system for propylparaben, a broadly used preservative in skin creams. The microsponge technology was employed to control the release of propylparaben, thereby reducing the risk of skin irritation and other adverse effects. The optimized microsponge formulation was incorporated into a cold cream and evaluated for its physical properties, in vitro release profile, and preservative efficacy. The results reveal that the microsponge-loaded propyl paraben provided sustained release and improved preservative activity, ultimately extending the shelf life of the cold cream. This innovative formulation offers a promising approach to enhancing the safety and effectiveness of skin creams. Particle size analysis showed that as the amount of polymer in the formulation increased, the particle size range of the batches also grew. Differential Scanning Calorimetry studies of the pure drug, ethyl cellulose, and propyl paraben-loaded microsponges revealed no interactions between the drug and the excipients. Similarly, Infrared spectroscopy analysis confirmed the absence of any interactions. Antimicrobial preservative testing conducted in a microbiology lab revealed the diameter of the zone of inhibition for the prepared microsponges, cold cream with the microsponges, and plain cream, demonstrating the antimicrobial potential of the microsponge-based formulation.