Hepatic Stellate Cell TM4SF1 Accelerates Hepatic Fibrosis Progression via Interacting With the Tyrosine Kinase c-Src
TM4SF1 promotes HF progression and HSC activation by binding to and activating c-Src. TM4SF1 could be a future therapeutic target for HF by inhibiting HSC activation.
Authors
- Zhiwei Huang (ORCID: https://orcid.org/0000-0002-6312-7434)
- Wenguang Fu (ORCID: https://orcid.org/0000-0003-3672-9728)
- Jian Ruan (ORCID: https://orcid.org/0000-0002-2076-9744)
- Peng Tan (ORCID: https://orcid.org/0000-0001-6992-9000)
- Bingyu Ren (ORCID: https://orcid.org/0000-0003-3663-8180)
- Wenhao Yu (ORCID: https://orcid.org/0000-0003-2991-5362)
- Jiatong Chen (ORCID: https://orcid.org/0000-0003-4156-8287)
- Ying‐Jun Chen (ORCID: https://orcid.org/0000-0002-8068-2894)
- Jiang Zhonghao
- Lei Sun (ORCID: https://orcid.org/0000-0003-0231-2465)
- Boyuan Gu
Institutions
- Southwest Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Qujiang People's Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
Publication Details
- Journal
- Cellular and Molecular Gastroenterology and Hepatology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.jcmgh.2025.101559
- Primary Topic
- Liver physiology and pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Southwest Medical University
- Natural Science Foundation of Sichuan Province