A biomimetic multimodal nanoplatform combining neutrophil-coated two-dimensional metalloporphyrinic framework nanosheet and exendin-4 to treat obesity-related osteoporosis
In summary, our study illustrates that excessive mitophagy plays a crucial role in obesity-induced osteoporosis. Furthermore, DPA@NM@CTZE exhibits significant potential for the precise treatment of obesity-induced osteoporosis, mitigating the side effects of Ex-4, and enhancing the bone microenvironment.
Authors
- Dong Zhu (ORCID: https://orcid.org/0000-0002-6700-2743)
- Shun Liu
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-5306-8338)
- Weijie Zhang (ORCID: https://orcid.org/0000-0002-8194-7786)
- Jing Liu (ORCID: https://orcid.org/0000-0002-3588-2969)
- Bin Liu (ORCID: https://orcid.org/0000-0003-2189-9476)
- Maosheng Zhang (ORCID: https://orcid.org/0000-0002-6212-1129)
- Qifan Yang (ORCID: https://orcid.org/0000-0001-7934-5463)
- Shuqi Zhang (ORCID: https://orcid.org/0000-0002-1709-8505)
- Xiaokang Wei
- Yanwei Liu
- Yilin Yang
Institutions
- Jilin University (CN)
- Jinan Maternity And Care Hospital (CN)
- First Hospital of Jilin University (CN)
- Shandong Maternal and Child Health Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Materials Today Bio
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1016/j.mtbio.2025.102009
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- First Hospital of Jilin University