Morphological Comparative Changes in Skin Healing by Using Postbiotic Cream and Antibiotics in Rabbit

The present study was done at the College of Veterinary Medicine, Kerbala University. The purpose of the study was to examine the properties of antibiotics (penicillin-streptomycin) and a postbiotic cream (Cicalfate+ cream) on the shape of rabbits' healing processes in full-thickness skin wounds. In forty-five healthy adult bucks weighing 1.3 and 1.8 kg, full-thickness wounds measuring 2.5 x 2.5 cm were made in the dorsal back area. Intramuscular injections of xylazine hydrochloride (5 mg/kg), ketamine hydrochloride (35 mg/kg) were given very quickly (IM), along with 1 mg/kg of diazepam. In group A, one group received a daily intramuscular injection of procaine penicillin G (80,000 U/kg of body weight) along with probenecid (25 mg/kg of body weight) and streptomycin (20 mg/kg of body weight) for five days. In group B, participants applied cicalfate+ cream topically twice a day. Group C served as a control group and did not receive any treatment. On the 3rd, 7th, and 14th days after wounding, the fifteen male adult rabbits that were chosen for the morphological investigation were separated into three subgroups of five. All groups showed different rates of epidermal re- and de-generation, although the one using Cicalfate+ cream showed the fastest skin wound healing progress, according to the morphological results.