STING-ΔN, a novel splice isoform of STING, modulates innate immunity and autophagy in response to DNA virus infection
STING-∆N acts as a potent negative regulator of the cGAS-STING pathway, revealing a previously unrecognized regulatory mechanism by which alternative splicing modulates immune responses to DNA viruses. These findings suggest that STING-∆N could be a promising therapeutic target for modulating immune responses in viral infections, autoimmune diseases, and cancer.
Authors
- Pei‐Hui Wang (ORCID: https://orcid.org/0000-0001-6853-2423)
- Shijun J. Zheng (ORCID: https://orcid.org/0000-0001-9462-4794)
- Chenghao Li (ORCID: https://orcid.org/0000-0002-9060-9527)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-4965-7076)
- Jian Deng
- Tao Li (ORCID: https://orcid.org/0000-0001-7343-9688)
Institutions
- Shandong University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s12964-025-02305-w
- Citations
- 2
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 1.59
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province
- National Key Research and Development Program of China