Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study

The study identified tumour coexistence, elevated inflammatory markers (serum TNF, CSF IL-8) and increased serum IgG levels as substantial factors associated with poor prognosis in anti-NMDAR encephalitis. These findings underscore the importance of early tumour screening and inflammatory marker monitoring in clinical management. However, larger multicentre studies are required to validate these results and provide more comprehensive guidance for clinical practice.

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Publication Details

Journal
Internal Medicine Journal
Published
2025-06-21
DOI
https://doi.org/10.1111/imj.70129
Primary Topic
Autoimmune Neurological Disorders and Treatments
Type
article
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article

Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study

Wangshu Xu, Chen Li, De‐Cai Tian, Han Zhao et al.
Internal Medicine Journal
Autoimmune Neurological Disorders and Treatments
article

Multifactorial analysis of clinical prognosis in patients with anti‐N‐methyl‐D‐aspartate receptor encephalitis: a single‐centre cohort study

Wangshu Xu, Chen Li, De‐Cai Tian, Han Zhao, Jiang Cao, Futang Xie, Chunxia Zhao
article en

Abstract

The study identified tumour coexistence, elevated inflammatory markers (serum TNF, CSF IL-8) and increased serum IgG levels as substantial factors associated with poor prognosis in anti-NMDAR encephalitis. These findings underscore the importance of early tumour screening and inflammatory marker monitoring in clinical management. However, larger multicentre studies are required to validate these results and provide more comprehensive guidance for clinical practice.

Internal Medicine JournalVol. 55(9)
Soochow University (CN), Beijing Tian Tan Hospital (CN), Qinhuangdao Second Hospital (CN), Fifth Tianjin Central Hospital (CN), First Hospital of Qinhuangdao (CN)
No poverty
Openalex Percentile: Top 77%
Autoimmune Neurological Disorders and Treatments
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