Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli

This is the first report in which a lysine biosensor constructed in E. coli could dynamically regulate cadaverine synthesis to improve its yield and biomass. This strategy provides new insights into the metabolic engineering of lysine and its derivatives in E. coli.

Authors

Haorong Chen
Shuchun Liu
Yukun Chen (ORCID: https://orcid.org/0000-0001-5523-3942)
Shuwen Liu
Tingyi Wen (ORCID: https://orcid.org/0000-0003-2583-7088)
Pengyu Chen (ORCID: https://orcid.org/0000-0002-6519-9079)
Mingjie Li (ORCID: https://orcid.org/0000-0003-4510-7330)

Institutions

Institute of Mechanics (CN)
University of Chinese Academy of Sciences (CN)

Publication Details

Journal: Microbial Cell Factories
Published: 2025-06-21
DOI: https://doi.org/10.1186/s12934-025-02772-3
Citations: 4
Primary Topic: Viral Infectious Diseases and Gene Expression in Insects
Type: article
Field-Weighted Citation Impact: 3.22

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article

Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli

Haorong Chen, Shuchun Liu, Yukun Chen, Shuwen Liu et al.

Jun 21, 2025

4 citations

Microbial Cell Factories

Viral Infectious Diseases and Gene Expression in Insects

3.22

article

Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli

Haorong Chen, Shuchun Liu, Yukun Chen, Shuwen Liu, Tingyi Wen, Pengyu Chen, Mingjie Li

June 21, 2025article en

4 citations

Abstract

This is the first report in which a lysine biosensor constructed in E. coli could dynamically regulate cadaverine synthesis to improve its yield and biomass. This strategy provides new insights into the metabolic engineering of lysine and its derivatives in E. coli.

Microbial Cell FactoriesVol. 24(1)

Institute of Mechanics (CN), University of Chinese Academy of Sciences (CN)

Openalex Percentile: Top 8%

Viral Infectious Diseases and Gene Expression in Insects

3.22

DOI Open Access PDF OpenAlex

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Development of a lysine biosensor for the dynamic regulation of cadaverine biosynthesis in E. coli — Haorong Chen, Shuchun Liu, et al. · Microbial Cell Factories (2025) | TGRS Research Map | TGRS