Unveiling hepatitis B biomarkers through genomic network analysis
Abstract Background The infection caused by the Hepatitis B virus (HBV) poses a significant challenge to global health. However, identifying and prioritizing functional biomarkers associated with the disease will allow more focused efforts for pre-clinical investigation. This study aimed to employ advanced genomic networks and bioinformatics tools to prioritize biomarkers for HBV. Results Comprehensive curation from six well-known databases yields a set of 495 HBV-associated genes based on gene ontology enrichment, pathway enrichment and protein–protein interaction analyses. Further functional gene network analyses identified 10 hub genes ( IL-6 , TNF , STAT3 , CD4 , IL-10 , STAT1 , IL-1B , AKT1 , IL-2 , and TLR4 ), warranting further investigation. Among these genes, IL-6 , TNF , and STAT3 emerged as promising biomarkers for HBV through CytoHubba analysis. Conclusions Overall, this study offers a genomic network-centric approach to identify and prioritize potential HBV biomarkers to provide valuable insights into its pathogenesis.
Authors
- Lalu Muhammad Irham (ORCID: https://orcid.org/0000-0002-0091-4887)
- Rockie Chong
- Ichtiarini Nurullita Santri (ORCID: https://orcid.org/0000-0001-9422-8716)
- Wirawan Adikusuma (ORCID: https://orcid.org/0000-0001-9165-690X)
- Firdayani Firdayani
- Rahmat Dani Satria (ORCID: https://orcid.org/0000-0002-7910-4325)
- Yohane Vincent Abero Phiri (ORCID: https://orcid.org/0000-0003-2376-4188)
- Dian Ayu Eka Pitaloka (ORCID: https://orcid.org/0000-0002-8187-8864)
- Made Ary Sarasmita (ORCID: https://orcid.org/0000-0002-2846-8786)
Institutions
- Udayana University (ID)
- University of California, Los Angeles (US)
- Universitas Gadjah Mada (ID)
- National Institute of Informatics (JP)
- Universitas Ahmad Dahlan (ID)
- University of Muhammadiyah Mataram (ID)
- Rumah Sakit Umum Pusat Dr. Sardjito (ID)
- National Nuclear Energy Agency of Indonesia (ID)
- University at Buffalo, State University of New York (US)
- Padjadjaran University (ID)
Publication Details
- Journal
- Egyptian Journal of Medical Human Genetics
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1186/s43042-025-00739-y
- Primary Topic
- Hepatitis B Virus Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Badan Riset dan Inovasi Nasional
- Lembaga Pengelola Dana Pendidikan