Acute kidney injury at the onset of type 1 diabetes mellitus: a balance between kidney stress and nephron mass
Our findings suggest a potential interplay between nephron mass and kidney stress in AKI development at T1DM onset. While uromodulin levels alone were not associated with AKI, a higher urinary uromodulin-to-NGAL ratio - possibly reflecting better-preserved nephron mass under stress - may be linked to a reduced risk of AKI. Further confirmation is needed.
Authors
- Mariantonia Braile (ORCID: https://orcid.org/0000-0002-3067-217X)
- Francesca Maisto
- Anna Di Sessa (ORCID: https://orcid.org/0000-0002-5877-3757)
- Pierluigi Marzuillo (ORCID: https://orcid.org/0000-0003-4682-0170)
- Dario Iafusco (ORCID: https://orcid.org/0000-0002-9398-3856)
- Angela Zanfardino (ORCID: https://orcid.org/0000-0003-0641-1321)
- Grazia Cirillo (ORCID: https://orcid.org/0000-0002-7823-972X)
- Stefano Guarino (ORCID: https://orcid.org/0000-0002-0551-5236)
- Emanuele Miraglia del Giudice
- Paola Tirelli (ORCID: https://orcid.org/0009-0008-3882-0940)
Institutions
- University of Campania "Luigi Vanvitelli" (IT)
Publication Details
- Journal
- Hormone Research in Paediatrics
- Published
- 2025-06-21
- DOI
- https://doi.org/10.1159/000547090
- Citations
- 2
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 2.86